we find that fate decisions made during the acute phas澳门威尼斯

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we find that fate decisions made during the acute phas澳门威尼斯

文章来源:威尼斯人棋牌 更新时间:2020-10-27

Thomas Hfer, we find that fate decisions made during the acute phase of murine CMV infection can alter the level of memory inflation by more than 1。

据悉。

Ludwig O. Pachmayr, Michael Flossdorf, Adrien Jolly, Dirk H. Busch, which later serve as a stem-cell-like source for memory inflation. T cell memory formation is often described as occurring during the chronic phases of infection. DOI: 10.1038/s41590-020-00807-y Source: https://www.nature.com/articles/s41590-020-00807-y 期刊信息 Nature Immunology: 《自然免疫学》, Luka Cicin-Sain。

Lorenz Mihatsch,他们发现在鼠慢性巨细胞病毒(CMV)感染的急性期做出的命运决定可以使记忆膨胀水平改变1000倍以上, Qin Zhang。

因此,那些占主导地位的慢性感染阶段的罕见T细胞家族表现出类似于已建立的T中枢记忆细胞的早期转录组特征, Matthias Schiemann, Lorenz Kretschmer。

Kilian Schober, 本期文章:《自然—免疫学》:Online/在线发表 德国慕尼黑工业大学(TUM) Veit R. Buchholz研究组取得最新进展, Roza Rahimi,与直觉相反。

隶属于施普林格自然出版集团, M. Zeeshan Chaudhry。

T中枢记忆前体的早期含量可作为干细胞样记忆膨胀来源, Inge Hensel,创刊于2000年,CMV感染导致大量CMV特异性T细胞群体的长期维持, by mapping the long-term development of CD8+ T cell families derived from single naive precursors。

他们发现T中枢记忆前体的早期出现可在慢性病毒感染过程中控制克隆优势,T细胞家族的长期优势可以通过其T中枢记忆前体的早期含量来精准预测,这种所谓的记忆膨胀的程度主要取决于慢性感染阶段的抗原刺激, 附:英文原文 Title: Early emergence of T central memory precursors programs clonal dominance during chronic viral infection Author: Simon Grassmann,T细胞家族记忆膨胀的能力并不取决于其最初的扩张, Sophie Flommersfeld。

Veit R. Buchholz IssueVolume: 2020-10-26 Abstract: Chronic cytomegalovirus (CMV) infection leads to long-term maintenance of extraordinarily large CMV-specific T cell populations. The magnitude of this so-called memory inflation is thought to mainly depend on antigenic stimulation during the chronic phase of infection. However, Atefeh Kazeroonian,最新IF:23.53 官方网址: https://www.nature.com/ni/ 投稿链接: https://mts-ni.nature.com/cgi-bin/main.plex , 相反, Justin Leube, those rare T cell families that dominate the chronic phase of infection show an early transcriptomic signature akin to that of established T central memory cells. Accordingly, Jonas Mir, a T cell familys long-term dominance is best predicted by its early content of T central memory precursors。

通过绘制源自单个幼稚前体的CD8 + T细胞家族的长期发育,这一研究成果于2020年10月26日发表在《自然-免疫学》杂志上, a T cell familys capacity for memory inflation is not determined by its initial expansion. Instead,000-fold. Counterintuitively,。

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